Advances in Melanoma, an Issue of Hematology/Oncology Clinic (Hardcover)
 
作者: David Fisher 
分類: Oncology ,
Dermatology  
書城編號: 1279215


售價: $900.00

購買後立即進貨, 約需 18-25 天

 
 
出版社: Elsevier Saunders
出版日期: 2009/06/18
尺寸: 229x155x15mm
重量: 499 grams
ISBN: 9781437704884

商品簡介
The field of melanoma biology has experienced a remarkable surge in recent years, owing to progress which has ranged from the most basic laboratory/preclinical discoveries to clinical developments that have begun to transform the management and prognosis for at least certain melanoma patients. Among the key areas that have contributed to this progress are studies relating to signaling and transcriptional pathways that regulate control over differentiation and survival of the melanocyte lineage. The identification of recurring activating mutations in specific signaling factors (B-RAF, N-Ras, c-KIT), amplification of other melanoma oncogenes (MITF, NEDD9), and the crucial recognition that certain of these genomic events occur within melanomas arising with specific clinical features (eg mucosal or acral origin) have led to clear recognition that melanoma is indeed "many different diseases." While the various subclasses of melanoma may share common features, such as profound invasive and metastatic propensity, it is also likely that sharply focused therapeutic strategies may exploit the functionally critical molecular engines, which distinguish these subclasses. Certain strategies focus upon the immunogenicity and striking clinical opportunities afforded by immune modulation, while others focus more directly on tumor-specific targeting. This issue brings together some of the leaders who have contributed significant insights from basic melanoma biology to progress in the clinic.
David Fisher 作者作品表

The War Magician: The Man Who Conjured Victory in the Desert (MP3 CD)

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eBook: Doctor Who: The Androids of Tara (Target Collection) (DRM EPUB)

The War Magician: The man who conjured victory in the desert (Paperback)

eBook: Executive Order: A Novel (DRM EPUB)

eBook: Morality and the Bomb: An Ethical Assessment of Nuclear Deterrence (DRM EPUB)

eBook: Morality and the Bomb: An Ethical Assessment of Nuclear Deterrence (DRM PDF)

eBook: Cultural Theory and Psychoanalytic Tradition (DRM EPUB)

eBook: Cultural Theory and Psychoanalytic Tradition (DRM PDF)

Complete Photo Guide to Soap Making (Paperback)

eBook: Romain Rolland and the Politics of the Intellectual Engagement (DRM EPUB)

eBook: Romain Rolland and the Politics of the Intellectual Engagement (DRM PDF)

eBook: Bill O'Reilly's Legends and Lies: The Civil War (DRM EPUB)

Bill O'Reilly's Legends and Lies: The Civil War (Hardcover)

Bill O'Reilly's Legends and Lies: The Patriots (hardcover)

eBook: Bill O'Reilly's Legends and Lies: The Patriots (DRM EPUB)

Bill O'Reilly's Legends and Lies: The Real West

eBook: Secret Life of Kim Dotcom: Spies, Lies and the War for the Internet (DRM EPUB)

Doctor Who and the Leisure Hive (Hardcover)

Morality and War (Paperback)

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