Covering all forty-five women from Martha Washington to Melania and Ivanka Trump and including the daughters, daughters-in-law, and sisters of presidents who served as First Ladies, Caroli explores each woman's background, marriage, and accomplishments and failures in office. This remarkable lot included Abigail Adams, whose "remember the ladies" became a twentieth-century feminist refrain; Jane Pierce, who prayed her husband would lose the election; Helen Taft, who insisted on living in the White House, although her husband would have preferred a judgeship; Eleanor Roosevelt, who epitomized the politically involved First Lady; and Pat Nixon, who perfected what some have called "the robot image." They ranged in age from early 20s to late 60s; some received superb educations for their time, while others had little or no schooling. Including the courageous and adventurous, the ambitious, and the reserved, these women often did not fit the traditional expectations of a presidential helpmate.

First Ladies is an engaging portrait of how each First Lady changed the role and how the role changed in response to American culture. These women left remarkably complete records, and their stories offer us a window through which to view not only this particular sorority of women, but also the role of American woman in general.