This four volume Major Work brings together the key articles that laid the foundations, extended and deepened the techniques, and demonstrated the application of the empirical-methodological toolbox of modern positive political science. The fundamental challenges of positive, empirical political science are many, and this collection helps to untangle and delineate the various issues by structuring the contents into four thematic sections:

- Multicausality

- Heterogeneity & Context Conditionality

- Temporal & Unit (Inter)Dependence

- Ubiquitous Endogeneity

The rationale behind the collection's structure and selection of contents is carefully laid out and explained in an illuminating introductory chapter, written by esteemed editor Robert J. Franzese.