1. Overview of Colorectal Cancer Joseph C. Anderson and Douglas J. Robertson 2. Colorectal Cancer Screening Tests and Recommendations Don C. Rockey 3. CTC Background and Development Darren Boone, Stuart A. Taylor and Steve Halligan 4. Indications and Evidence for CTC Elizabeth G. McFarland 5. Performance and Interpretation of CTC Christopher F. Beaulieu and Peter D. Poullos 6. Integration of CTC into a CRC Screening Program Stephen Carpenter 7. CTC Controversies (Radiation exposure, Extracolonic findings, Cost-effectiveness) Andrea Laghi, Franco Iafrate, Maria Ciolina and Paolo Baldassari 8. CTC Pitfalls/Limitations Donald W. Jensen and Duncan Barlow 9. Future Directions/Innovations with CTC (Prepless CTC, Alternative displays, Computer aided detection) Farid Dahi and Abraham H. Dachman