Oda Nobunaga, Daimyo and head of the powerful Oda Clan, looks to reunify the fractured land. Defeating rival clans, the Shogun and even Buddhist rebels, Nobunaga now stands at the brink of his greatest victory. The Takeda Clan stands as the last great threat, with a hope that victory could mean unification.

As Japan wars, Jesuits, missionaries of Christianity look to spread their influence and faith on whoever comes out on top. In service to Alessandro Valignano, a trusted Italian missionary, a tall, large East African native is struggling with the thoughts of the past and wary of what his future could hold. He will one day go by the name... Yasuke.