This book explores the potential role of prebiotics, probiotics, and synbiotics in managing various metabolic disorders, chronic diseases, and metabolic syndromes. The initial chapter provides an overview of metabolic disorders, including their classification, symptoms, and underlying causes. Additionally, the chapter discusses the intricate signaling pathways and mechanisms through which prebiotics, probiotics, and synbiotics interact with the human body in relation to type-2 diabetes, obesity, Phenylketonuria, and Hemochromatosis. Additionally, the book highlights the potential impact of probiotics and synbiotics on oxidative stress, inflammation, lipid metabolism, and blood pressure. Further, the book focuses on the gut-brain axis and how synbiotics may influence neurotransmitter metabolism. With an emphasis on the gut-microbiota axis, this book presents a compelling narrative that explores the rationality behind synbiotic use and offers a glimpse into future perspectives for managing metabolic disorders effectively. This book is intended for researchers in the fields of nutraceuticals, nanomedicine, endocrinology, nutrition, gastroenterology, and metabolic medicine who are working in the field of probiotics, prebiotics, and symbiotics for the treatment of metabolic disorders.