Originally serialized in Love and Rockets New Stories, "Ti-Girls Adventures" managed to be both a rollickingly creative super-hero joyride (featuring three separate super-teams and over two dozen characters) that ranged from the other side of the universe to Maggie's shabby apartment, and a genuinely dramatic fable about madness, grief, and motherhood as Penny Century's decades-long quest to become a genuine super-heroine are finally, and tragically, fulfilled.

In addition to introducing a plethora of wild new characters, God and Science brings in many older characters from Jaime's universe, some from seemingly throwaway shorter strips and some from Maggie's day-to-day world (including some real surprises). The main heroine of the story, forming a bridge between the "realistic" Maggie stories and the super-heroic extravaganza is "Angel," Maggie's sweet-tempered and athletic new roommate and best friend, and now herself an aspiring super-heroine.

Aside from being presented in a large format that really displays Jaime Hernandez's stunning art, God and Science will be a "director's cut" version that includes a full 30 new pages in addition to the original 100-page epic, including four new full-color faux Ti-Girls covers, several expansions of scenes, an epilogue set back in Maggie's apartment, and a long fantasy/timewarp sequence that draws the focus back on Penny's awful predicament.