Defining Menopause: What Is Early, What Is Late.- Etiologies of Premature Ovarian Insufficiency.- Signs and Symptoms of Premature Ovarian Insufficiency.- Diagnosis of Premature Ovarian Insufficiency.- Mechanisms for Infertility Associated with Premature Ovarian Insufficiency and Failure.- Non-Reproductive Associations with Premature Ovarian Insufficiency and Failure.- Non-Invasive Methods for Enhancing Ovarian Function.- IVF and Egg Donation in Women with Premature Ovarian Insufficiency and Failure.- Treatment-Independent Conception in Premature Ovarian Insufficiency and Failure.- Mood Matters in Women with Premature Ovarian Insufficiency and Failure.- Future Shock: Can the Ovary Replenish Its Egg Supply?- When Pregnancy Is Not the Issue: Hormone Therapy and Long-Term Health Management.